Don't be afraid to take a chance.
Don't be afraid to branch out, especially if it's to try something outside the realm of what you know or think you want.
From the beginning of the film, Andy never thought she'd be a fashion editor. In fact, she completely wrote off the position at Runway, even though she was told repeatedly that it was the job a "million girls would kill for." Instead, she held onto her lifelong desire for wanting to be a journalist.
As for Miranda? Her idea of taking a chance was hiring someone who was completely inexperienced in fashion –– and it certainly was a decision that could have crashed and burned. But sometimes that's when the magic happens and you'll never know unless you take a leap of faith.